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Clinical Impact

Less VUS. More decisive answers.

When ACMG single-source classification is layered with ClinVar reciprocal lookups, variants of uncertain significance drop from 62.9% to 18.5% in primary findings — a 71% reduction in clinical ambiguity.

71%
VUS reduction
Source: GeneGenius H100 benchmark report (May 27, 2026), “Less VUS” section. Single-source baseline measured on cardiovascular_panel.vcf primary findings (May 23, 2026 internal analysis).